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A plant-human hybrid, Dr. Pamela Lillian Isley (Phd) is one of the world's most notorious eco-terrorists and botanists. She is obsessed with plants, botany, ecological extinction and environmentalism.

Ivy uses toxins from plants as well as mind-controlling pheromones for her criminal activities, which are usually aimed at protecting endangered species and the natural environment.

The dangerous experiments that transformed Pamela into Poison Ivy placed a deliberate overdose of plant and animal based toxins into her blood stream that make her touch potentially deadly while also allowing her to boost her immunity to all poisons, viruses, bacteria, and fungi. As a result of the experiments, her body produces pheromones that make people susceptible to mind control around her.

As a botanist, Pam specializes in plant hybrids and can create the most potently powerful floral toxins in Gotham City.

She also has an ability to encourage and direct the growth of plant life on a molecular level.

Poison Ivy has been identified by the Swamp Thing (Alec Holland) as a being with an elemental mystical component. She has shown an ability to use the Green, a force connected to plant life all over the planet and for a time was it's chosen avatar. She relinquished this to Alec but remains a firm defender of it.